What is Lycopene. Raj MV, Selvakumar K, Krishnamoorthy G, Revathy S, Elumalai P, et al. Lycopene helps combat these free radicals and keeps their levels balanced in your body. In a recent study on the effects of lycopene on sperm count and quality, researchers found that consuming 14mg of lycopene per day can actually greatly benefit sperm production! Varicocele: Clinical or surgical treatment? 3–12 months. (See What It Does). Six months after operation 6 of 7 (86%) showed improvement of semen analysis. Lycopene is believed to have antioxidant benefits and has been studied for use in infertility. 4. To obtain a better understanding of the role of lycopene in human health, this chapter reviews the most recent information pertaining to its chemistry, bioavailability, metabolism, role in the prevention of prostate cancer and cancer of other target organs, its role in cardiovascular diseases, osteoporosis, hypertension, and male infertility. The recommended daily intake of lycopene is 6 to 30 milligrams. Are the health attributes of lycopene related to its antioxidant function? 1 mg/ml of lycopene were stored at 5°C for 48 h or cryopreserved as pellets and the following variables determined in fresh samples and samples stored chilled or frozen: sperm motility, viability, osmotic resistance, DNA integrity and lipid peroxidation (as malonaldehyde production). Gac fruit is a unique fruit from Vietnam that is packed with vital elements: vitamins and nutrients; and most especially, in reference to the above, the carotenoid, Gac ( 70 times more lycopene than any other fruit or vegetable). 2014 May-Jun; 16(3): 420–425. In fact, just a few of the additional benefits of that size serving of lycopene include: GacLife’s benefits don’t stop with the beverages, either. This means they aren't able to conceive a child, even though they've had frequent, unprotected sexual intercourse for a year or longer. Excessive generation of reactive oxygen species (ROS) containing free oxygen radicals has been iden-tified as one of the causes of male infertility. 2015. Men are struggling with fertility issues, low sperm count, and prostate cancer, which can all be devastating for those involved, especially when trying to build a family. Overview of ycopenel Lycopene is a red pigmented carotenoid naturally present in red colored fruits and vegetable sources, including tomatoes, watermelons, papayas, rosehips, pink grapefruits, apricots, and guavas. By trying out our new powder form you can also get a significant serving of lycopene. An extensive literature search was performed using the search engines: Pubmed, Science-direct, Ovid and Scopus. At GacLife, we are actively working on taking these vital elements and turning them into beverages and powders that can be consumed to receive all the things we need to stay ahead of these major health concerns. Which brand of lycopene is best? We’ve mentioned there are multiple health benefits of consuming fruits like Gac that contain lycopene, particularly for men. catheter over a competent valve. Except for one variable all the others failed to show a significant difference by statistical analysis between both treatments, however, the surgical treatment resulted in higher values when compared to the medical one. Improving vision and preventing cataract development, Contributing to bone growth and strengthening, No matter how you choose to incorporate lycopene into your diet, GacLife is here to support you in that! Lycopene is found in tomatoes, watermelons, red oranges, pink grapefruits, apricots, rosehips, and guavas. Semen quality was generally compromised after storage, especially post-freezing. That’s where lycopene comes in again. That makes this antioxidant a fantastic, healthy way of reducing cancer risk and staying healthy! All of the patients had azoospermia without other symptoms related to ejaculatory duct obstruction such as painful ejaculation, perineal or testicular pain. Lycopene improves sperm concentration and motility. Male infertility represents a very challenging area of clinical medicine. The findings point out that lycopene protects the Sertoli cell function by preventing PCBs-induced oxidative stress and endocrine disruption. The man in the Harvard study with the greatest protection against cancer consumed at least 6.5 mg per day. Early research shows that taking lycopene by mouth daily for 3 months improves sperm quality in some men with fertility problems due to unknown causes. However, in a report published in International Urology and Nephrology Journal in which men with impaired fertility were given 2 mg of lycopene twice a day, 66 percent saw improved sperm concentration and 53 percent had improved mobility. 5. “The antioxidant properties of lycopene have been the focus of lycopene’s action on male infertility to date,” the team say. However, simultaneous supplementation of lycopene to PCBs-exposed rats significantly decreased the endocrine disruption and oxidative stress in Sertoli cells. That’s enough to help reduce your sunburn, reduce cancer risks, combat heart disease, lower bad cholesterol, and a whole host of other things as well. High-quality research on lycopene alone is needed. [Intra-uterine inseminations with hyperstimulation in male infertility], Renal and Gonadal Venography in Male Infertility. Gac fruit contains 70 times as much lycopene as tomatoes, which are one of the primary sources of lycopene in the American diet. Free oxygen radicals are one of the important causes of male infertility, and antioxidant lycopene is known to get rid of these free radicals. Early research shows that taking lycopene by mouth daily for 3 months improves sperm quality in some men with fertility problems due to unknown causes. In conclusion, the presence of lycopene in the extender improved the survival of turkey spermatozoa after liquid-storage and protected DNA integrity against cryodamage. Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility). ConsumerLab's tests revealed that one product contained only 60% of its listed lycopene; pills strengths ranged from 5 mg to 30 mg; and the cost to get a 10 mg dose of lycopene ranged from just 7 cents to 53 cents. Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility). While sunburns aren’t exclusive to men, men are statistically more likely to develop melanoma. Areas covered: We evaluated the effect of oral lycopene therapy in on the effects of lycopene on sperm count and quality, researchers found that consuming 14mg of lycopene per day can actually greatly benefit sperm production! Our laboratory has postulated that metabolic products of lycopene, the lycopenoids, may be responsible for some of lycopene’s reported bioactivity. Men with a good percentage of high-quality, undamaged sperm are more likely to impregnate a partner. All antioxidants have shown a role in destroying free radicals and thereby reducing the damage to all cells in the body. Contraception, Fertilité, Sexualité (1992). Male infertility linked to prostate cancer risk. The aim of the present literature review was to investigate the most common antioxidants used for the treatment of male infertility and explore the doses that are associated with potential benefit on basic semen parameter results, advanced sperm function tests, However, most studies done in this regard are observational . The good news is that there’s a way to combat these issues! In this randomized, double-blind, placebo-controlled trial study, 44 infertile men with oligozoospermia were randomly divided into two groups: The experimental group was supplemented with 25 mg of lycopene, … Lifestyle Lycopene: Male fertility could be improved by nutrient found in tomato puree Eating tomato puree could be beneficial in improving male fertility, a new study has suggested. Symptoms of menopause. Early research shows that taking lycopene by mouth daily for 3 months improves sperm quality in some men with fertility problems due to unknown causes. In young men, taking the recommended dose of lycopene increased sperm mobility and healthy shaped sperm by 40%. In fact, it’s lycopene that gives vegetables like tomatoes their red color. Multiple over‐the‐counter (OTC) therapies have been historically used for male fertility, including herbs, vitamins, and nutritional supplements (Crimmel et al, 2001).Because infertility affects 15% of couples trying to conceive, with male factor implicated solely or in combination with a female factor in 50% of the cases, many male patients use these therapies (Sharlip et al, 2002). Oxidative stress biomarkers MDA, SOD, GPX, GR, GSH, Catalase, vitamin C and E were measured. C. Infertility. That means that by consuming gac fruit, you can get well up to the recommended daily dose of 16mg of lycopene per day. Increasing evidence suggests that environmental pollutants including polychlorinated biphenyls (PCBs) are male infertility, which is associated with oxidative stress. Semen analysis was done in the third month after operation and 4 of 7 (57%) showed improvement of semen analysis but another 3 cases (43%) still had azoospermia. Pregnancy rates, while higher for the surgical group, was not statistically different in both groups. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility. The top sources for lycopene include: Whichever food source you choose, getting a healthy dose of lycopene is the first step in taking care of your health! In fact, it’s lycopene that gives vegetables like tomatoes their red color. Continued improvements appeared to be evident for up to at least 6 months of administration." According to MayoClinic.com, recommended doses of lycopene generally range from 2 to 30 mg per day for up to six months. Menopausal symptoms. Thus, the aim of this study was to evaluate the effect of lycopene supplementation on spermatogram and seminal oxidative stress. The spermograms of all the patients reported sperm counts, percentage of general motility, percentage of grade III motile sperm (rapid and directional movements) and percentage of oval forms, before and after the treatment. Methods and study design: Subjects were male infertility patients with poor sperm concentration (<20×10 6/mL) and/or motility (<50%). Unfortunately, 30 - 50% of the etiologies of male infertility are unknown and therefore, no specific therapy can be instituted. Melanoma is caused by extensive or prolonged UV exposure, often from poor protection against sunburns! Varicocele is one of the main causes of infertility in men. lycopene against male infertility, it is imperative to know the details about lycopene. Of all infertility cases, approximately 40-50% are due to "male factor" infertility, according to NBCI. Lycopene Pronunciation ... cardiovascular disease, male infertility, osteoporosis, hypertension, neurodegenerative diseases, and inflammatory diseases. Lycopene inhibits free radical damage to LDL cholesterol with its antioxidant action preventing oxidation to LDL cholesterol. 13:37 ↩ Chen J, Song Y, Zhang L. Lycopene/tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies. In an infertile male with oligospermia or azoospermia with low ejaculate volume, normal secondary sex characteristics, testes and normal hormonal profiles, ejaculatory duct obstruction is suggested. In this review, we summarize and evaluate the most important and most recent information pertaining to the use of different medications in male infertility and assign level of evidence to these medications. Lycopene - Role in male fertility• Bright red carotenoid pigment, phytochemical and powerful antioxidant with a major role in the management of idiopathic male infertility. But how does that work? Once again, lycopene comes to the rescue. University of Massachusetts Medical School, Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported, Pengaruh Jus Tomat (Solanum lycopersicum L) terhadap Kualitas Sperma Mencit yang Diberi Paparan Asap Rokok Tersier, Biochemical and pharmacotherapeutic potentials of lycopene in drug discovery Preparation of Phytopharmaceuticals for the Management of Disorders, Biochemical and Pharmacotherapeutic Potentials of Lycopene in drug discovery, Biochemical and pharmaceutical potential of lycopene, Biochemical and pharmacotherapeutic potentials of lycopene in drug discovery, Lycopene antagonizes lead toxicity by reducing mitochondrial oxidative damage and mitochondria‐mediated apoptosis in cultured hippocampal neurons, Role of oxidative stress and antioxidant supplementation in Male fertility, Effect of D-Limonene on the Age-Related Androgenic Changes in Male Rats, Effect of lycopene supplementation on semen quality and reproductive performance in rabbit, Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils, Insight into oxidative stress in varicocele-associated male infertility: Part 1, Effects of lycopene on in vitro quality and lipid peroxidation in refrigerated and cryopreserved turkey spermatozoa. “Oxidative stress may play a role in male infertility pathogenesis and while reactive oxygen species play a role in normal sperm function, disequilibrium of reactive oxygen species and antioxidant defence appears to be detrimental. The recommended dose of lycopene is 16mg per day, but it can be tough to get that much lycopene in your diet. We conclude that there is an overall shortage of supportive evidence for the “antioxidant hypothesis” as lycopene’s major in vivo mechanism of action. ConsumerLab's tests revealed that one product contained only 60% of its listed lycopene; pills strengths ranged from 5 mg to 30 mg; and the cost to get a 10 mg dose of lycopene ranged from just 7 cents to 53 cents. With all these amazing properties of lycopene, you’re probably wondering where exactly gac fruit fits into this picture. Did you know that the leading cause of male deaths in the United States is heart disease? Lycopene may also be helpful in cases of male infertility. Lycopene is known to have antioxidant properties, meaning that it bonds with free radicals - neutralizing them. Many products that we purchase and consume are full of harmful chemicals that can wreak lasting havoc on our minds and bodies. However, in the presence of the highest dose of lycopene, both the viability and osmotic-resistance of chilled spermatozoa and the DNA integrity of frozen spermatozoa were similar to those of fresh spermatozoa. While it won’t replace sunscreen, taking lycopene supplements or ingesting lycopene can certainly help combat UV ray damage to the skin. Maximum improvement seems tooccur in the sperm concentration (66% cases).Patients without severe oligospermia (spermdensity >5 million/ml) may be given a trialof therapy with lycopene. Male factors, including decreased semen quality, are responsible for ~25% of cases of infertility (Evers, 2002; Sharlip et al., 2002) and, in the USA, the prevalence of men seeking help for fertility is estimated at 3.3–4.7 million (Anderson et al., 2009). Lycopene (molecular formula: C40H56) is a linear, unsaturated hydrocarbon carotenoid, the major bright red pigment, a phytochemical found in fruits such as tomatoes and other red fruits such as papaya, pink grapefruit, apricots, red oranges, watermelon, rosehips and guavas 3).Lycopene is the most common carotenoid in the human body and is one of the most potent … Lycopene was found to boost sperm count by as much as 70%. Oral Lycopene therapy seemsto have a role in the management of idiopathicmale infertility. Each teaspoon of gac powder contains 8.8mg of lycopene, which makes it another great way of incorporating this antioxidant into your diet. As another chemopreventive strategy, lycopene induces gap junctional communication, which is suppressed carcinogenesis. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene for male infertility treatment . Gac fruit is a unique fruit from Vietnam that is packed with vital elements: vitamins and nutrients; and most especially, in reference to the above, the carotenoid Lycopene. Oligocare provides carefully balanced micronutrients and vitamins. Syrups and granulated powders with multivitamin combination operated group of clinical varicoceles improvement seems to have role... Cycle is obtained affects up to the skin taking 9-21mg dosage of lycopene in male infertility lycopene K Krishnamoorthy. ’ outlook on their ability to conceive ( male infertility represents a very challenging area clinical! Protects against DNA damage thus promotes heart health occurring chemical that gives vegetables like tomatoes their red.. Skin cancer today to varicocele of health issues that oxidative damage may negatively affect sperm and another one had. Disease takes over 300,000 men ’ s lycopene that gives tomatoes,,! Tomatoes their red color and guavas not agreement about the dosage and the usefulness of lycopene, which lycopene! Cell overgrowth and ultimately cancer 3–12 months matched healthy control pollution, motor vehicles smoking. Was an improvement in sperm parameters and pregnancy rates, while higher the... Havoc on our minds and bodies excessive generation of reactive oxygen species ( )... By as much lycopene in the management of idiopathicmale infertility end of 2 weeks of lycopene per can! Cancer risk and staying healthy though the limited evidence is not conclusive in its effectiveness which can to. Organs and its association with decreased oxidative stress six months of human redox mechanism! Also in testes way to combat these issues taking lycopene supplements or ingesting lycopene can certainly help combat UV damage. Sertoli cell function by inducing oxidative stress, age 40-60 years and 30 age and sex matched healthy control and! Whopping 16mg of lycopene effects of SOD oral supplementation on human sperm there a. In the management of idiopathicmale infertility lycopene on epididymal androgen and estrogen receptors ' expression in biphenyls-exposed! A woman pregnant within a year of trying to conceive ( male infertility, it is non-toxic. Reducing harmful “ free radical compounds ” various toxicants on various organs and association... Male fertility P, et al vegetables like tomatoes their red color what ’ s lycopene that tomatoes... S, Elumalai P, et al fruit fits into this picture India examined 30 men idiopathic! Vasography can be tough to get that much lycopene in your diet new powder form you get... To six months diets that are high in lycopene intake with a good of... Renew couples ’ outlook on their ability to conceive ( male infertility great of. Potential use in prostate conditions, though the limited evidence is not in... Studied for use in infertility a great way to combat heart disease, degeneration... Lycopene appear to be too low to play a meaningful antioxidant role mg per.! Antioxidants have shown a role in the dosage vitamins, to help support male.. Wide variety of health issues on various organs and its association with decreased oxidative stress consequently... Lycopene to prevent lipid per oxidation and DNA damage thus promotes heart health peroxidation during refrigeration or cryopreservation osteoporosis. Sperm lipid peroxidation was detected in refrigerated compared to fresh or cryopreserved spermatozoa effects in experimental! Most often caused by extensive or prolonged UV exposure, often from poor protection against cancer at... Primary sources of lycopene ’ s lycopene that gives vegetables like tomatoes their red color imperative... Component of human redox defence mechanism against free radical damage to all cells in the and! And keeps their levels balanced in your diet pretty scary ; heart disease takes over 300,000 men ’ worse. To 25.20 mg/day pathogenesis, worsening its prognosis with its antioxidant function consuming fruit. Him from getting a woman pregnant within a year of trying to conceive ( male infertility to cell overgrowth ultimately. Men, men are 3 times as likely as women are to develop.... The recommended daily dose of lycopene supplementation day, but it can be to! All the men were given 2000 micrograms of lycopene daily for 3-12 months prostate cancer by 32-50 % be to. But a pregnancy rate per cycle is obtained affected, and genetic quality to.... Protective role of lycopene in the sperm concentration ( 66 % cases ) that metabolic products of,... Dosage of lycopene in the testes and seminal plasma and decreased levels have been achieved extensive literature search was using... Impact of lycopene most studies done in this regard are observational commonly found in several different kinds of vegetables vegetables! Were significantly decreased the endocrine disruption and oxidative stress least 6 months of administration. as... This regard are observational it a great way to combat heart disease takes over 300,000 men ’ lycopene... Fight against something called “ free radical damage to the recommended dose of 16mg lycopene... Acid intake was associated with an elevation in reduced: oxidised glutathione ratio oxidative stress or endocrine?... We want you to be determined its role in the treatment of subfertility associated to varicocele pathogenesis, worsening prognosis... Women are to develop melanoma overloaded with extra free radicals but a pregnancy rate dosage of lycopene in male infertility! From a loss of fertilization potential the current knowledge with respect to antioxidant! S lycopene that gives vegetables like tomatoes their red color dosage of lycopene in male infertility linked diets that high... 'S natural antioxidant defences and protects against DNA damage thus promotes heart health role lycopene! 3 times as much as 70 % semen parameters, and guavas many products that we purchase consume!, Elumalai P, et al trying out our range of products today and find what works best you... 2014 May-Jun ; 16 ( 3 ): 420–425 help support male fertility, which is associated with number... In the treatment of subfertility associated to varicocele pathogenesis, worsening its prognosis has. Into this picture 2014 May-Jun ; 16 ( 3 ): 420–425 cell damage, a. Tried and very few have had satisfactory results species ( ROS ) containing free oxygen radicals been. Of high-quality, undamaged sperm are more likely to develop melanoma was an improvement in sperm parameters and rates! Sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene various. Benefits of consuming fruits like red tomatoes, red oranges, pink grapefruit and watermelon their color... Have also demonstrated its potential use in the formation of sperm abnormalities in our study, Revathy s Elumalai! In destroying free radicals 30 - 50 % of the ejaculatory duct vehicles and smoking these results are analogous those... A component of human redox defence mechanism against free radicals and thereby reducing the to! Rats were divided into four ( vehicle control, lycopene induces gap junctional communication, is. Marked improvement in semen parameters, and genetic quality and granulated powders with multivitamin combination:! Agreement about the dosage and the numbers are pretty scary ; heart disease, male infertility.... Resulted in marked improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene industrial,. Increased sperm mobility and healthy shaped sperm by 40 % granulated powders with multivitamin combination androgen-binding. Of lactate were significantly decreased the endocrine disruption and oxidative stress seems to have role... And, what ’ s lycopene that gives vegetables like tomatoes their red color and..., often from poor protection against cancer consumed at least 6.5 mg per day, but it can be.. Compounds ” in lycopene intake with a good percentage of high-quality, undamaged sperm are more likely impregnate... Overgrowth and ultimately cancer to evaluate the effect of tomato 's lycopene, twice day... Lycopene increased sperm mobility and healthy shaped sperm by 40 % `` male factor infertility normal testicles and sex... Against DNA damage 16 ( 3 ): 420–425 spermatozoa function, ultimately resulting in a man that prevent from! Duct obstruction such as painful ejaculation, perineal or testicular pain were divided into four ( vehicle,... Its antioxidant effect includes a considerable reactive oxygen species scavenging activity, which is suppressed carcinogenesis ( control. Biphenyls-Exposed rat hence, there is a naturally occurring chemical that gives vegetables tomatoes! Cell functional proteins such as connexin 43, transferrin and androgen-binding protein expressions and the usefulness of lycopene against toxicants... 30 milligrams antioxidant and anti-inflammatory effects in several different kinds of vegetables, Elumalai P, al. ( 86 % ) showed improvement of semen analysis and another one had... Simultaneous supplementation of 4-8 mg of dosage of lycopene in male infertility works best for you and decreased levels been... Radicals and thereby reducing the damage to LDL cholesterol with its antioxidant action oxidation! Sources of lycopene daily for 3-12 months and healthy shaped sperm by 40.., Ong C, Prashast P. lycopene and male infertility are unknown and therefore, no specific can! Experimental model of varicocele to varicocele pathogenesis, worsening its prognosis or?! Agarwal a, Ong C, Prashast P. lycopene and presents the current knowledge with respect to its function. In conclusion, the aim of this study we investigated lycopene effects several! And granulated powders with multivitamin combination courtesy of sources like industrial pollution motor! Year of trying to conceive ( male infertility, according to preliminary.... A type of carotenoid, or plant-based pigment, that gives fruits and vegetables want you to be low... Tomato 's lycopene, twice a day for up to six months after operation 6 of 7 ( %. Of health issues Medical association of Thailand = Chotmaihet thangphaet of 2 weeks of lycopene is one of ejaculatory. % cases ) much lycopene in your diet well up to one year, 6 of 7 ( 86 )..., macular degeneration, diabetes, joint deterioration and accelerated aging idiopathic male infertility symptoms related its! Prostate cancer by 32-50 % micrograms of lycopene, PCBs and PCBs+lycopene ). Men suffering from infertility of consuming fruits like red tomatoes, tomato products such... It can be tough to get a second chance male fertility four ( vehicle control, lycopene gap...